The 14 Best Clinical Strength Antiperspirants & Deodorants in 2024: Protection for Extreme Sweating

It’s 11:30 in the morning, and you already feel your sweat seep through your shirt… even though you applied antiperspirant right after your shower. Does this scenario sound familiar? If so, consider switching to a stronger antiperspirant designed for people who excessively sweat. Keep reading for some of the best clinical strength antiperspirants on the market.

Sweat is an essential mechanism used by our bodies to cool us down and regulate body temperature. However, some people sweat excessively regardless of the temperature or their level of physical exertion. This is typically caused by a medical condition called hyperhidrosis.

One of the easiest ways to treat hyperhidrosis without seeing a doctor is to use clinical strength antiperspirants, like the ones we've highlighted in this article.

1. Duradry PM Antiperspirant Gel
2. Odaban Antiperspirant Spray
3. Arm & Hammer UltraMax Antiperspirant Deodorant
4. Dove Men+Care Clinical Antiperspirant Deodorant Stick
5. SweatBlock Clinical Strength Antiperspirant Wipes
6. Gillette Clinical Strength Antiperspirant and Deodorant 
7. Mitchum Men Clinical Soft Solid Antiperspirant
8. Carpe Clinical Grade Underarm Antiperspirant
9. ZeroSweat Original Clinical Strength Antiperspirant
10. Maxim Prescription Strength Antiperspirant & Deodorant
11. Uriage Power 3 Clinical Strength Antiperspirant Roll-On
12. Degree Men Clinical Antiperspirant & Deodorant
13. Certain Dri Everyday Strength Clinical Antiperspirant Deodorant
14. SweatStop Antiperspirant

This post was originally published in April 2020, and was updated in March 2021, January 2022, December 2022, and January 2024.

How To Use Clinical Strength Deodorant or Antiperspirant

One of the most important things to know when using a clinical strength antiperspirant or deodorant is how to properly use it. Here are some tips to get the best out of your deodorant.

• Apply the deodorant or antiperspirant to your underarms and areas where you sweat the most, or where visible sweat marks appear.
• Experts advise you to apply the product to clean skin at night instead of in the morning, which is a popular practice. This gives the active ingredients the necessary time to properly absorb and block your sweat pores.
• Use only the recommended amount to avoid skin irritation.
• Consider shaving or trimming your armpit hair to give the product a chance to make direct contact with your skin. With less hair under your arms, there is less chance for sweat to collect and mix with bacteria.

Now let’s get into the crux of this article to answer the probing question: what are the best clinical strength deodorants and antiperspirants?

1. Duradry PM Antiperspirant Gel

Don't let sweaty armpits keep you from living your best life. Look to Duradry PM Gel Antiperspirant, formulated with aluminum chloride hexahydrate and salicylic acid, to fight sweat and odor. As the name states, this antiperspirant is designed to be applied at bedtime to clean, dry skin. Only a pea-sized amount is needed for full protection. It comes in a neutral scent that doesn't interfere with other fragrances, and won’t leave any residue on clothing. (Buy on Amazon)

For best results, use with Duradry AM Deodorant & Antiperspirant

2. Odaban Antiperspirant Spray

Odaban Antiperspirant Spray comes in easily transportable 30 ml bottles and can be used on most areas of the body. Its pump spray application contains the precise amount of antiperspirant formula to avoid over-spraying which can lead to irritation. The antiperspirant is designed to feel gentle yet effective, with dryness lasting up to 24 hours. The full effects should be noticeable after a few days of usage. (Buy on Amazon)

3. Arm & Hammer UltraMax Antiperspirant Deodorant

Arm & Hammer’s UltraMax Antiperspirant Deodorant is a serious contender for the best deodorant for hyperhidrosis. This product is an excellent option in regard to function and price. It provides maximum strength all-day protection against sweat and odor. This invisible solid goes on clear so it won’t stain clothing or leave a residue on your skin. It is also unscented, so you can wear your favorite cologne without worrying about competing scents.  (Buy on Amazon)

4. Dove Men+Care Clinical Antiperspirant Deodorant Stick

One of the best prescription strength antiperspirants designed for men is the Dove Men+Care Clinical Antiperspirant Deodorant Stick. It delivers powerful protection against wetness and odor for up to 48 hours. It has a crisp scent to keep you feeling fresh all day. To protect against irritation, it’s designed with moisturizing technology that is gentle on your skin. The antiperspirant can be applied in the morning; but for the best protection, apply it at night. This allows the formula to set in. (Buy on Amazon)

5. SweatBlock Clinical Strength Antiperspirant Wipes

SweatBlock is a clinical strength antiperspirant that comes in the form of wipes. Once in regular use, the effects can keep you dry for up to seven days. For first-time users, use for four consecutive days and then apply as needed. The wipes are more effective when applied to clean skin at night before bed. SweatBlock antiperspirant wipes are scented and individually packaged. (Buy on Amazon)

6. Gillette Clinical Strength Antiperspirant and Deodorant

Gillette Clinical Strength Antiperspirant and Deodorant neutralizes odor while providing advanced, yet gentle, clinical strength sweat protection for up to 72 hours. It comes equipped with powerful triple protection technology for clinical strength protection equivalent to a 6.25% aluminum chloride prescription product. This product is dermatologist-tested and is formulated with skin conditioners to prevent skin irritation. One swipe in each armpit is all that’s needed. (Buy on Amazon)

7. Mitchum Men Clinical Soft Solid Antiperspirant

Mitchum Clinical Solid Unscented Deodorant offers powerful protection against sweat and odor. This clinical-strength formula keeps you confidently fresh throughout the day. Stay dry and comfortable with long-lasting effectiveness, ensuring reliable performance without compromising on skin comfort. (Buy on Amazon)

8. Carpe Clinical Grade Underarm Antiperspirant 

Stay dry and confident all day long! This clinical grade antiperspirant from Carpe prevents sweat, shirt stains, and bad odors associated with excessive sweating. This product combines all-natural ingredients like activated charcoal to absorb sweat and clinical grade sweat-controlling active ingredients for lasting sweat protection. It is also designed to be gentle on your skin. No irritation, burning and itching often associated with prescription-strength antiperspirants. (Buy on Amazon)

9. ZeroSweat Original Clinical Strength Antiperspirant

ZeroSweat is one of the best clinical strength antiperspirants to combat hyperhidrosis without resorting to costly medical procedures. This roll-on antiperspirant should be applied at night, so you can start your day with dry armpits. ZeroSweat ensures dryness for up to 7 days with one bottle lasting for up to 3 months. (Buy on Amazon)

10. Maxim Prescription Strength Antiperspirant & Deodorant

Maxim’s Prescription Strength Antiperspirant & Deodorant provides maximum protection with a few simple half strokes of the roll-on applicator before bed. You can also apply your regular deodorant as normal after showering in the morning. To combat the effects of hyperhidrosis, Maxim provides dryness for up to 7 days with its alcohol-free, prescription strength formula. (Buy on Amazon)

11. Uriage Power 3 Clinical Strength Antiperspirant Roll-On

Experience long-lasting freshness with Uriage Roll-On Deodorant. This clinical-strength antiperspirant provides effective protection against odor and wetness. Its gentle formula, enriched with Uriage Thermal Water, ensures comfort and skin hydration. Stay confidently dry throughout the day. (Buy on Amazon)

12. Degree Men Clinical Antiperspirant & Deodorant

When considering the best men's deodorant for excessive sweating, check out Degree Men Clinical Antiperspirant & Deodorant. It is Degree’s most powerful product to combat excessive sweat. This antiperspirant deodorant also features MotionSense technology, which is motion-activated odor protection that lasts throughout the day. It works best when applied at night to allow it to work while you sleep. (Buy on Amazon)

13. Certain Dri Everyday Strength Clinical Antiperspirant Deodorant

Certain Dri brings another excellent product to the list with its Everyday Strength Clinical Antiperspirant Deodorant. This clinical strength deodorant for excessive sweating, or hyperhidrosis, provides effective sweat and odor protection all day long. The active ingredient in this formula is 20% Aluminum Zirconium Complex to block sweat. It is also safe to apply to other areas of your body that may be prone to sweat. For best results, apply at night to clean and dry skin. (Buy on Amazon)

Also available in Prescription Strength Spray.

14. SweatStop Antiperspirant

As stated in the name, this antiperspirant aims to stop excessive sweat, helping you to manage hyperhidrosis. SweatStop has a range of antiperspirant products for different areas of the body including the underarms, hands and feet, forehead, and head. Application methods vary among roll-ons, sprays, and lotion. The range of products and formulas makes this brand one of the best prescription strength antiperspirants. (Buy on SweatStop website)

If your current antiperspirant or deodorant has left you anything but dry, try out one of these clinical strength antiperspirants and clinical strength deodorants designed to combat excessive sweating. Make sure to follow the product's application guidelines to get the best results. 

Take Control of Your Sweat and Odor

To ensure all-day protection, wear an Ejis sweat proof undershirt. (Buy from our shop or on Amazon.) Our sweat proof undershirts are designed to protect your shirts from sweat marks and stains. They are also infused with real silver to fight odor-causing bacteria.

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